Metformin as a geroprotector.
نویسنده
چکیده
Abstract Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established. The goal of this review is to investigate the evidence for the geroprotective effect of metformin and to describe the possible mechanisms behind it.
منابع مشابه
P-56: Effect of Metformin and Orlistat on OvulatoryStatus in Obese PCOS Patients
Background: Polycystic Ovary Syndrome (PCOS) is the commonest cause of anovulatory infertility. Treatment modes available are numerous. The use of anti-obesity medications such as orlistat or insulin sensitizing agents such as metformin is sometimes indicated in these patients. We aimed to compare the effect of metformin vs orlistat on the hormone, lipid profile &ovulation status in obese PCOS ...
متن کاملSynthesis of 1,4-disubstituted 1,2,3-triazoles Catalyzed by Eggshell-supported-Cu(I) Metformin Complex as a Heterogeneous Catalyst in Water
An efficient and eco-friendly method has been developed for the synthesis of 1,4 disubstituted 1,2,3-triazoles using the eggshell-supported-Cu(I) metformin complex as a natural and heterogeneous catalyst. The catalyst prepared is characterized by FT-IR spectroscopy, SEM, and ICP techniques. Terminal alkynes were successfully reacted with alkyl chloride and sodium azide in the presence of CuI im...
متن کاملI-40: Relationship Between Abnormal GlucoseTolerance Test and History of Previous Recurrent Miscarriages, and Beneficial Effecof Metformin in These Patients: A Prospective Clinical Study
Background: To determine the incidence of an abnormal glucose tolerance test in patients with recurrent spontaneous abortion and whether metformin would safely reduce the rate of first trimester spontaneous abortions in patients without polycystic ovary syndrome (PCOS) as well as with PCOS and an abnormal glucose tolerance test. Materials and Methods: Patients with a history of recurrent sponta...
متن کاملP118: Metformin; A Review to its Anti-Neuroinflammatory Properties
Neuroinflammatory disorders include a wide spectrum of disorders in which immune system injures components of the nervous system. Despite the advances in therapy, lack of efficient curative therapies for these disorders not only affects the quality of life but also places huge burden on the society. These limitations have necessitated therapeutic interventions for developing more efficient regi...
متن کاملTHE EFFECT OF ENDURANCE TRAINING IN MATERNAL METABOLIC SYNDROME WITH METFORMIN ON OXIDANT AND ANTIOXIDANT CAPACITY IN THEIR NEONATES
Background: High oxidative stress in pregnant women leads to pathogenesis or progression of disease in newborns. The aim of this study was to investigate the Effect of Endurance Training in Maternal Metabolic Syndrome with Metformin on Oxidant and antioxidant Capacity in their Neonates. Methods: To implementation of this experimental research, 16 female Wistar rats weighing 100 ± 20 gr randoml...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Rejuvenation research
دوره 14 5 شماره
صفحات -
تاریخ انتشار 2011